An efficient approach to isoquinoline via AgNO3-promoted 6-endo-dig cyclization followed by oxidative elimination of o-alkynylarylaldimines and its application in fluoride recognition was written by Tang, Yongxing;Yu, Yajun;Wei, Xinyu;Yang, Jin;Zhu, Yeting;Zhao, Yun-Hui;Tang, Zilong;Zhou, Zhihua;Li, Xiaofang;Yu, Xianyong. And the article was included in Tetrahedron Letters in 2019.Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:
A novel 6-endo-dig cyclization followed by oxidation/elimination of o-alkynylbenzaldehydes with 4-hydroxybenzylamine was developed for preparation of isoquinolines. The intermediates of this tandem reaction were monitored by mass spectroscopy (MS) to confirm the reaction pathway. This methodol. was further applied to the design and synthesis of a novel ratiometric chemosensor for determination of fluoride. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics