An expeditious approach to 1-(isoquinolin-1-yl)guanidines via a three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, with carbodiimide was written by Wang, Huanhuan;Ye, Shengqing;Jin, Hanpeng;Liu, Jianping;Wu, Jie. And the article was included in Tetrahedron in 2011.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:
A small library of 1-(isoquinolin-1-yl)guanidine is constructed efficiently via a silver triflate-catalyzed three-component reaction of 2-alkynylbenzaldehydes, tosyl hydrazine, and carbodiimides. The preliminary biol. screens of these isoquinoline library members have been evaluated, which show promising results for PTP1B inhibition and HCT-116 inhibition. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics