Bronsted acid-promoted dimerization of o-alkynylbenzaldehydes: a one-step synthesis of functionalized Kagan’s ether analogues was written by Zhang, Hao;Cui, Wei-Chen;Hu, Zhi-Long;Yu, Shu-Yan;Wang, Shaozhong;Yao, Zhu-Jun. And the article was included in RSC Advances in 2012.Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:
The Bronsted acid-promoted dimerization of o-alkynylbenzaldehydes has been discovered and studied in the presence of 45% aqueous HBF4 in acetic acid. The developed cascade methodol. provides a convenient one-step synthesis of sym. 2,3,6,7-dibenzo-9-oxabicyclo[3.3.1]nona-2,6-diene (Kagan’s ether) analogs bearing various functionalities. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics