Palladium-catalyzed coupling of α-halo vinylphosphonate and α-phosphonovinyl sulfonate with alkylzincs: straightforward and versatile synthesis of α-alkyl vinylphosphonates was written by Zhang, Li;Fang, Yewen;Jin, Xiaoping;Guo, Ting;Li, Ruifeng;Li, Yan;Li, Xie;Ye, Qilin;Luo, Xiang. And the article was included in Organic Chemistry Frontiers in 2018.Application of 6294-17-3 The following contents are mentioned in the article:
With α-(pseudo)halo vinylphosphonate as the electrophilic coupling partner, a variety of alkyl- and benzylic zinc reagents underwent vinylation reactions to produce α-alkyl vinylphosphonates. This unprecedented Pd-catalyzed Negishi coupling features mild reaction conditions, high functional group tolerance, broad substrate scope, retention of the olefin geometry, and easy gram-scale synthesis. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 6294-17-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics