Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639 was written by Zhang, Qingwei;Xia, Zhiren;Joshi, Shailen;Scott, Victoria E.;Jarvis, Michael F.. And the article was included in ACS Medicinal Chemistry Letters in 2015.Application In Synthesis of 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride The following contents are mentioned in the article:
The discovery of a novel peripherally acting and selective Cav3.2 T-type calcium channel blocker, ABT-639 I, is described. HTS hits, which have poor metabolic stability, were optimized to obtain a lead, which has improved stability and oral bioavailability. Modification of the lead to further improve ADME properties led to the discovery of I. Following oral administration, I produces robust antinociceptive activity in exptl. pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat. This study involved multiple reactions and reactants, such as 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride (cas: 866763-17-9Application In Synthesis of 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride).
2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride (cas: 866763-17-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics