Silver Nitrate Mediated Cyclization/N-N Bond-Cleavage Reaction for the Synthesis of 3-Arylisoquinolines was written by Zhao, Yun-Hui;Li, Yubo;Luo, Mingjian;Tang, Zilong;Deng, Keqin. And the article was included in Synlett in 2016.Name: 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:
An unprecedented silver nitrate mediated novel transformation of aromatic hydrazones (R1)(2-H2NN=C)C6H3CCR2 (R1 = H, 4-Cl, 5-F, 4-Me, 4-MeO; R2 = C6H5, 4-ClC6H4, 4-H3COC6H4, etc.) into various isoquinolines I (X = H, 6-F, 7-Cl, 7-Me, 7-MeO) has been developed. This method involves a silver nitrate promoted cyclization of aromatic hydrazones followed by N-N bond cleavage, and has wide substrate scope under mild conditions. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Name: 5-Chloro-2-(phenylethynyl)benzaldehyde).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: 5-Chloro-2-(phenylethynyl)benzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics