Blazheevs’kii, M. E. published the artcileQuantitative determination of decamethoxine in drug formulations by enzyme kinetic method, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Visnik Farmatsii (2007), 13-15, database is CAplus.
An enzyme kinetic method for the decamethoxine (DM; cationic surfactant with antimicrobial and disinfectant effects) determination by enzyme kinetic method based on DM inhibition of acetylcholine hydrolysis by cholinesterase (horse serum acyl hydrolase, EC 3.1.1.8) was developed. The indicator reaction for acetylcholine utilizes p-anisidine oxidation by peracetic acid formed in the auxiliary reaction of acetylcholine perhydrolysis with H2O2. The reaction product was measured by spectrophotometry at 358 nm. Comparison of the degree of inhibition of the enzymic reaction in the presence of standard and test samples allows to find the DM level in the formulation. The relative standard deviation at 1-2 μg DM/mL is ≤6%. The lower quantification limit (at 20% reaction inhibition) is 1 ng/mL. The method was used for DM detn in Septefril 0.0002 g tablets.
Visnik Farmatsii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
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