Boodhoo, Nitish published the artcileGlutaminolysis and glycolysis are essential for optimal replication of Marek’s disease virus, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Journal of Virology (2020), 94(4), e01680-19, database is CAplus and MEDLINE.
Marek’s disease virus causes a deadly lymphoproliferative disease in chickens and modulates metabolism of host cells. Metabolic anal. of MDV-infected chicken embryonic fibroblasts identified elevated levels of metabolites involved in glutamine catabolism, such as glutamic acid, alanine, glycine, pyrimidine, and creatine. In addition, our results demonstrate that glutamine uptake is elevated by MDV-infected cells in vitro. Although glutamine, but not glucose, deprivation significantly reduced cell viability in MDV-infected cells, both glutamine and glucose were required for virus replication and spread. In the presence of min. glutamine requirements based on optimal cell viability, virus replication was partially rescued by the addition of the tricarboxylic acid (TCA) cycle intermediate, α-ketoglutarate, suggesting that exogenous glutamine is an essential carbon source for the TCA cycle to generate energy and macromols. required for virus replication. Surprisingly, the inhibition of CPT1a, which is elevated in MDV-infected cells, by chem. (etomoxir) or physiol. (malonyl-CoA) inhibitors, did not reduce MDV replication, indicating that MDV replication does not require fatty acid β-oxidation Taken together, our results demonstrate that MDV infection activates anaplerotic substrate from glucose to glutamine to provide energy and macromols. required for MDV replication, and optimal MDV replication occurs when the cells do not depend on mitochondrial β-oxidation
Journal of Virology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.
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