Burns, Mark R. published the artcileStructural correlation between lipophilicity and lipopolysaccharide-sequestering activity in spermine-sulfonamide analogs, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(24), 6209-6212, database is CAplus and MEDLINE.
Lipopolysaccharides (LPS), otherwise termed endotoxins, are outer-membrane constituents of Gram-neg. bacteria, and play a key role in the pathogenesis of Septic Shock, a major cause of mortality in the critically ill patient. We had previously defined the pharmacophore necessary for small mols. to specifically bind and neutralize this complex carbohydrate. A series of aryl and aliphatic spermine-sulfonamide analogs were synthesized and tested in a series of binding and cell-based assays in order to probe the effect of lipophilicity on sequestration ability. A strong correlation was indeed found, supporting the hypothesis that endotoxin-neutralizing ability involves a lipophilic or membrane attachment event. The research discussed herein may be useful for the design of addnl. carbohydrate recognizing mols. and endotoxin-neutralizing drugs.
Bioorganic & Medicinal Chemistry Letters published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Related Products of chlorides-buliding-blocks.
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