Tetrahedron published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.
Gioti, Efthymia G. published the artcileA new scalable synthesis of entecavir, Application In Synthesis of 7080-50-4, the publication is Tetrahedron (2018), 74(4), 519-527, database is CAplus.
A new synthesis of entecavir from D-glucose in an average total yield of 3.5% was achieved via an intramol. nitrile oxide cycloaddition (INOC) reaction and a Peterson olefination as key-steps. The present process was designed for industrial application, using widely available raw materials, simple and cheap reagents and avoiding low reaction temperatures, which are very common in the synthetic approaches towards similarly complex structures.
Tetrahedron published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics