Hoyerova, Klara published the artcileAuxin molecular field maps define AUX1 selectivity: many auxin herbicides are not substrates, Application of 3-Chloro-4-hydroxyphenylacetic acid, the publication is New Phytologist (2018), 217(4), 1625-1639, database is CAplus and MEDLINE.
Summary : Developmental responses to auxin are regulated by facilitated uptake and efflux, but detailed mol. understanding of the carrier proteins is incomplete. We have used pharmacol. tools to explore the chem. space that defines substrate preferences for the auxin uptake carrier AUX1. Total and partial loss-of-function aux1 mutants were assessed against wild-type for dose-dependent resistance to a range of auxins and analogs. We then developed an auxin accumulation assay with associated math. modeling to enumerate accurate IC50 values for a small library of auxin analogs. The structure activity relationship data were analyzed using mol. field analyses to create a pharmacophoric atlas of AUX1 substrates. The uptake carrier exhibits a very high level of selectivity towards small substrates including the natural indole-3-acetic acid, and the synthetic auxin 2,4-dichlorophenoxyacetic acid. No AUX1 activity was observed for herbicides based on benzoic acid (dicamba), pyridinyloxyacetic acid (triclopyr) or the 6-arylpicolinates (halauxifen), and very low affinity was found for picolinic acid-based auxins (picloram) and quinolinecarboxylic acids (quinclorac). The atlas demonstrates why some widely used auxin herbicides are not, or are very poor substrates. We list mol. descriptors for AUX1 substrates and discuss our findings in terms of herbicide resistance management.
New Phytologist published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Application of 3-Chloro-4-hydroxyphenylacetic acid.
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