Hrinovets, I. S. published the artcileJustification of formulation of dental films with decamethoxine as medicinal preparation for treatment of mucous membrane diseases, Computed Properties of 38146-42-8, the publication is Farmatsevtichnii Zhurnal (Kiev, Ukraine) (2008), 99-103, database is CAplus.
Therapeutic drug delivery systems in the form of dental medicinal films with pharmacol. ingredients with prolonged wound-healing, antibacterial, anti-inflammatory, and regenerative activities for use in stomatol. practice were studied. The mucosa-adhesive films containing 0.02% of the antiseptic and disinfecting agent decamethoxine were prepared from methylcellulose, polyvinyl alc., polyvinylpyrrolidone, and gelatin; the auxiliary components were propylene glycol, PEO-400, Tween-80, saccharin, and water. The medicinal films were evaluated for sensory, taste, physicochem., microbiol., and biopharmaceutical properties, including thickness, adhesivity, UV absorption spectra, solubility and drug release in water and in mouth. The decamethoxine levels were determined by spectrophotometry at 540 nm. The antimicrobial activity was examined against test strains of Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, and Candida albicans at 37°. The films had pronounced antibacterial effects on G-pos. and less on G-neg. bacteria. The films were also tested in patients with mouth mucosa inflammation and ulcerative damage. The dry films were stable during 24-mo storage.
Farmatsevtichnii Zhurnal (Kiev, Ukraine) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Computed Properties of 38146-42-8.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics