Huerta, Pedro L. published the artcileSynthesis of various geometric and enantiomeric oxime O-(α- and β-methylcholinyl) ethers as potential anticholinergic agents, Quality Control of 4584-49-0, the publication is Journal of Pharmaceutical Sciences (1977), 66(8), 1120-4, database is CAplus and MEDLINE.
Various enantiomeric and geometric oxime O-(α- and β-methylcholinyl) ethers were prepared as potential anticholinergic agents. The synthesis, separation, resolution, and structural characterization of these compounds are reported. The 1st step of the synthetic pathway involved an oxime formation, with subsequent O-alkylation of the resp. oxime with 2-chloro-N,N-dimethylpropylamine hydrochloride. The separation of the α- and β-structural isomers utilized vacuum fractional distillation and/or column chromatog., and the resolution of the enantiomers was accomplished via the formation of tartrate diastereoisomers. A preliminary pharmacol. evaluation for anticholinergic activity was conducted using a rat ileum assay. Structure-activity relationships, including some stereochem. properties and antimuscarinic activity, are discussed.
Journal of Pharmaceutical Sciences published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Quality Control of 4584-49-0.
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