Kuramochi, Takahiro published the artcileDiscovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: a potent and orally bioavailable NCX inhibitor, Product Details of C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry (2005), 13(12), 4022-4036, database is CAplus and MEDLINE.
Ca2+ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca2+ overload, because NCX inhibitors can directly inhibit the influx of Ca2+ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives We have discovered a novel NCX inhibitor (I) with an IC50 value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P 450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of I are discussed.
Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Product Details of C6H4ClNO2.
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