Markus, Astrid published the artcileMicrobial degradation of 4-chlorophenylacetic acid. Chemical synthesis of 3-chloro-4-hydroxy-, 4-chloro-3-hydroxy- and 4-chloro-2-hydroxyphenylacetic acid, Safety of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie (1982), 363(4), 431-7, database is CAplus and MEDLINE.
Pseudomonas CBS 3 converts 4-chlorophenylacetic acid partly into 3-chloro-4-hydroxy-, 4-chloro-3-hydroxy-, and 4-chloro-2-hydroxyphenylacetic acid by the action of monooxygenases. However, these compounds are not intermediates in the degradation of 4-chlorophenylacetic acid. Pseudomonas CBS 3 cannot grow with 3-chloro-4-hydroxy- and 4-chloro-3-hydroxyphenylacetic acid as sole C sources. 4-Chloro-2-hydroxyphenylacetic acid is slowly degraded, forming 4-chloro-2,3-dihydroxyphenylacetic acid. The actual degradation of 4-chlorophenylacetic acid seems to be initiated by the attack of a dioxygenase. The syntheses of 4-chloro-3-hydroxyphenylacetic acid and of 4-chloro-2-hydroxyphenylacetic acid are described.
Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Safety of 3-Chloro-4-hydroxyphenylacetic acid.
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