Nadirova, Maryana A. published the artcileCascade of the Hinsberg / IMDAF reactions in the synthesis 2-arylsulfonyl-3a,6-epoxyisoindoles and 4a,7-epoxyisoquinolines in water, Name: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, the publication is Tetrahedron (2021), 132032, database is CAplus.
N-Furfuryl allylamines, readily accessible from corresponding furfurals or furfuryl amines, react with a broad range of aryl sulfonyl chlorides with the formation of a 3a,6-epoxyisoindoles I [Ar = Ph, 2-thienyl, Ts, etc.; R1 = H, I, Et, etc.; R2 = H, Br, Me] in one synthetic stage was reported. Usually, in boiling water, the interaction sequence involved two consecutive steps: the Hinsberg reaction and the intramol. Diels-Alder furane (IMDAF) reaction. The scope and limitations of the proposed method were thoroughly investigated, and it was revealed that the key [4+2] cycloaddition step proceeded through an exo-transition state, giving rise to the exclusive formation of a single diastereomer of the target heterocycle. The method allowed the ability to obtain N-sulfaryl-substituted 3a,6-epoxyisoindoles I and 4a,7-epoxyisoquinolines, which were potentially useful substrates for further transformations and subsequent bioscreening, in particular antimicrobial activity.
Tetrahedron published new progress about 32333-53-2. 32333-53-2 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Sulfonyl chlorides,Benzene, name is 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride, and the molecular formula is C7H3Cl2F3O2S, Name: 4-Chloro-3-(trifluoromethyl)benzenesulfonyl Chloride.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics