Ngoma Tchibouanga, Remi Rolland published the artcile3-Chloro-4-hydroxyphenylacetic acid co-crystals with nicotinamide, isonicotinamide, phenazine and 4,4′-bipyridine: An investigation of synthon motifs, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid, the publication is Journal of Molecular Structure (2020), 127195, database is CAplus.
Multicomponent crystals of 3-chloro-4-hydroxyphenylacetic acid (CHPAA) with nicotinamide (NAM), isonicotinamide (INAM), phenazine (PHZN) and 4,4′-bipyridine (BIPY) were successfully synthesized by the slow evaporation technique. The co-crystals were characterized using x-ray diffraction, thermal anal., FTIR spectroscopy and Hirshfeld surface anal. Both NAM and INAM co-crystal structures exhibited O-H···N and N-H···O interactions. The INAM co-crystal structure demonstrated the tetrameric amide homosynthon. The incorporation of H2O into the NAM co-crystal structure resulted in addnl. O-H···O H bonds. PHZ and BIPY co-crystal structures displayed O-H···N interactions. The 2CHPAA•BIPY structure also showed an interesting CHPAA dimer with a head to tail motif characterized by O-H···O and formed a H bonded ring described as R22(18). Weaker interactions C-H···O, C-H···Cl and π ··· π stacking were also observed in the crystal structures. Alternate preparation methods such as grinding and slurry experiments were also explored. Crystallog. data are given.
Journal of Molecular Structure published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics