Palii, G. K. published the artcileStudy of Candida fungus sensitivity to antimicrobial drugs, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Antibiotiki i Meditsinskaya Biotekhnologiya (1986), 31(3), 218-20, database is CAplus.
Fifty strains of Candida (C. albicans 28, C. tropicalis 18, and C. pseudotropicalis 4 strains) were tested in vitro against 5 fungicides: amphotericin B, levorin, decamethoxine, enteroseptol, and intestopan. Decamethoxine was the most active drug, as it inhibited 78% of the strains at 0.08-6.25 μg/mL concentration; at 12.5 μg/mL, the drug showed fungicidal activity against 20% of the strains. Levorin and amphotericin B displayed antifungal activity at 50 μg/mL concentration At 3.9-7.8, μg/mL enteroseptol inhibited 78% of the strains. Intestopan was the least active compound Development of resistance to decamethoxine was slow, and there was no cross-resistance between decamethoxine and levorin.
Antibiotiki i Meditsinskaya Biotekhnologiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.
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