Pashynska, V. A. published the artcileModel mass spectrometric study of competitive interactions of antimicrobial bisquaternary ammonium drugs and aspirin with membrane phospholipids, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Biopolymers and Cell (2013), 29(2), 157-162, database is CAplus.
Aim: The aim of the study is to reveal mol. mechanisms of possible activity modulation of antimicrobial bisquaternary ammonium compounds (BQAC) and aspirin (ASP) through noncovalent competitive complexation under their combined introduction into the model systems with membrane phospholipids. Methods: Binary and triple systems containing either decamethoxinum or ethonium, or thionium and aspirin, as well as dipalmitoylphosphatidylcholine (DPPC) have been investigated by electrospray ionization mass spectrometry. Results: Basing on the anal. of associates recorded in the mass spectra, the types of nonocovalent complexes formed in the systems studied were determined and the supposed role of the complexation in the BQAC and ASP activity modulation was discussed. The formation of associates of BQA C dications with ASP anion is considered as one of the possible ways of deactivation of ionic forms of the medications. The formation of stable complexes of BQAC with DPPC and ASP with DPPC in binary systems as well as the complexes distribution in triple-components systems BQACASP:DPPC point to the existence of competition between drugs of these two types for the binding to DPPC. Conclusions: The results obtained point to the competitive complexation in the model mol. systems containing the BQAC, aspirin and membrane phospholipids. The observed phenomenon testifies to the possibility of nodularizing the activity of bisquaternary antimicrobial agents and aspirin under their combined usage, due to the competition between the drugs for binding to the target membrane phospholipid mols. and also due to the formation of stable noncovalent complexes between BQAC and ASP.
Biopolymers and Cell published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Safety of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.
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