Pashynska, V. A. published the artcileDimethyl sulfoxide as a functional agent for antimicrobial drug’s transport facilitating: mechanistic study by mass spectrometry, Synthetic Route of 38146-42-8, the publication is Functional Materials (2022), 29(1), 100-106, database is CAplus.
Electrospray ionization mass spectrometry (ESI MS) study has been performed to examine biol. significant intermol. interactions between the mols. of DMSO (DMSO, known as a functional agent for transdermal and transmembrane drug’s transfer facilitation) and some antimicrobial drugs. Formation of stable noncovalent complexes of DMSO with the mols. of antibiotics levofloxacin (LEF) and cycloserine (CYS) in the polar solvent methanol has been revealed by ESI MS probing of model binary systems of DMSO with the mentioned drugs. At the same time ESI MS investigation of the similar model systems containing DMSO and antimicrobial chemotherapeutic preparation decamethoxinum (DEC) has shown that any peaks of the noncovalent complexes between DMSO and DEC are not recorded in the mass spectra, that points to the dependence of DMSO-drug complexation peculiarities on the drug’s structure. The data of ESI MS examining of DMSO+d ipalm itoylp hosphatidyl choline model system reveal that the DMSO mols. also do not form stable noncovalent clusters with the membrane phospholipid mols. in the polar surrounding. The obtained results as to formation of stable noncovalent complexes of DMSO with LEF and CYS in the polar solvent are proposed to be considered as one of the possible mol. mechanisms of action of DMSO as transdermal and transmembrane penetration enhancer in drug delivery. The current study confirms the ESI MS method applicability to examining the DMSO complexation with the drugs mole-cules and biomols. with the purpose to predict the DMSO usage efficiency as an agent for the drug’s transdermal and transmembrane transport facilitating.
Functional Materials published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Synthetic Route of 38146-42-8.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics