Pashynska, V. A. published the artcileStudy of non-covalent complexes formation between the bisquaternary ammonium antimicrobial agent decamethoxinum and membrane phospholipids by electrospray ionization and collision-induced dissociation mass spectrometry, Category: chlorides-buliding-blocks, the publication is Visnik Kharkivs’kogo Natsional’nogo Universitetu im. V. N. Karazina (2004), 123-130, database is CAplus.
The noncovalent complex formation between the membrane phospholipid, dipalmitoylphosphatidylcholine, and the bisquaternary ammonium antimicrobial agent, decamethoxinum, which is related to its biol. activity, was studied by electrospray ionization (ESI) mass spectrometry and collision-induced dissociation (CID) tandem mass spectrometry. Stable doubly-charged complexes of the drug dication with phospholipid mol. assemblies containing up to nine phospholipid mols., which model drug-phospholipid interactions in biol. membrane systems, were registered. For examination of the structure and the stability characteristics of the drug-phospholipid noncovalent complexes, their CID spectra were examined The developed ESI mass spectrometry methodol. is proposed for fast screening of bisquaternary ammonium compounds with antimicrobial activity.
Visnik Kharkivs’kogo Natsional’nogo Universitetu im. V. N. Karazina published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Category: chlorides-buliding-blocks.
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