Shinohara, Naoki’s team published research in ChemMedChem in 7 | CAS: 6249-56-5

Shinohara, Naoki published the artcileSelective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is ChemMedChem (2012), 7(10), 1770-1773, S1770/1-S1770/7, database is CAplus and MEDLINE.

Polytheonamide B is an extremely cytotoxic natural product and is the largest nonribosomal peptide that has been described to date. Polytheonamide B is a linear chain polypeptide containing an N-terminal 5,5-dimethyl-2-oxohexanoate group (Ncap) and 48 amino acid residues of alternating D– and L-chirality; in addition, the secondary structure of this peptide was recently reported to be a remarkable β^6,3 helix with a length of approx. 45 Å. This helical tube structure is thought to function as a transmembrane ion channel in which the 4 Å hydrophobic pore provides a path for ion translocation. Planar bilayer experiments have previously demonstrated that the monomeric form of polytheonamide B functions as a monovalent cation-selective channel. The present work describes the synthesis of seven derivatives of polytheonamide B and examines the effect of N-terminal modification on cytotoxicity and ion channel activity.

ChemMedChem published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C20H17FO4S, Safety of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics