Adams, H. Jack published the artcilePrimary local anesthetic testing and acute toxicity of N,N’-disubstituted 2,3-diamino-2′,6′-propionoxylidides, SDS of cas: 18791-02-1, the publication is Journal of Pharmaceutical Sciences (1973), 62(10), 1677-9, database is CAplus and MEDLINE.
The local anesthetic activity of the 8 N,N’-disubstituted-2,3-diamino-2′,6′-propionoxylidides (I) and 1-tert-butyl-2-aziridinecarboxy-2′,6′-xylidide (II) [50603-33-3] which were prepared fell between that of lidocaine-HCl [73-78-9] and tetracaine-HCl [136-47-0]. None of the compounds possessed the long duration of tetracaine in the guinea pig wheal. All the compds were more toxic than tetracaine i.p. in the mouse and except for II they were less irritating than tetracaine in the rabbit intradermal wheal.
Journal of Pharmaceutical Sciences published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, SDS of cas: 18791-02-1.
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