Fang, Chao published the artcileDiscovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors, Computed Properties of 854778-30-6, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(22), 3529-3533, database is CAplus and MEDLINE.
Previous work established a coumarin scaffold as a starting point for inhibition of Mycobacterium tuberculosis (Mtb) FadD32 enzymic activity. After further profiling of the coumarin inhibitor 4 revealed chem. instability, the authors discovered that a quinoline ring circumvented this instability and had the advantage of offering addnl. substitution vectors to further optimize. Ensuing SAR studies gave rise to quinoline-2-carboxamides with potent antitubercular activity. Further optimization of ADME/PK properties culminated in I that exhibited compelling in vivo efficacy in a mouse model of Mtb infection.
Bioorganic & Medicinal Chemistry Letters published new progress about 854778-30-6. 854778-30-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (2-Chloro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H8BClO3, Computed Properties of 854778-30-6.
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