Gal, Noga published the artcileMembrane interactions of ionic liquids: Possible determinants for biological activity and toxicity, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Biochimica et Biophysica Acta, Biomembranes (2012), 1818(12), 2967-2974, database is CAplus and MEDLINE.
Ionic liquids (ILs) are a class of diverse organic salts with relatively low m.ps. (below 100 °C) which have attracted considerable interest as a promising “green” substitute for organic solvents. The broad solvation properties of ILs and their high solubility in water, however, present health risks, in particular since it was shown that many ILs exhibit cytotoxic properties. In this context, interactions of ILs with the cellular membrane are believed to constitute a primary culprit for toxicity. We present a comprehensive biophys. and microscopy study of membrane interactions of a series of ILs having different side-chain compositions and lengths, and cationic head-group structures and orientations. The exptl. data reveal that the ILs studied exhibit distinct mechanisms of membrane binding, insertion, and disruption which could be correlated with their biol. activities. The results indicate, in particular, that both the side chain composition and particularly the head-groups of ILs constitute determinants for membrane activity and consequent cell toxicity. This work suggests that tuning membrane interactions of ILs should be an important factor for designing future compounds with benign environmental impact.
Biochimica et Biophysica Acta, Biomembranes published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics