Hachey, D. L. published the artcileQuantitative analysis of methadone in biological fluids using deuterium-labeled methadone and GLC-chemical-ionization mass spectrometry, Category: chlorides-buliding-blocks, the publication is Journal of Pharmaceutical Sciences (1977), 66(11), 1579-82, database is CAplus and MEDLINE.
The (+)-, (-)-, and (±)-2H5-methadones which contained 5 deuterium atoms in 1 aromatic ring, were synthesized for use in clin. pharmacol. studies and as internal standards GLC-chem.-ionization mass spectrometry was used to determine plasma and urinary methadone [76-99-3] levels by an inverse isotope dilution assay. Plasma drug levels could be determined to 10 pmol/mL, and urine levels could be measured to 5 pmol/mL. Plasma methadone levels were examined in several patients undergoing methadone maintenance therapy. These levels generally ranged between 100 and 400 ng/mL (320-1300 pmol/mL) after an average oral dose of 1 mg/kg/day. The methadone half-life was 28.8 h.
Journal of Pharmaceutical Sciences published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Category: chlorides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics