Karimi, Farhad published the artcilePalladium-mediated carboxylation of aryl halides (triflates) or benzyl halides using [13C]/[11C]carbon monoxide with tetramethylammonium hydroxide or trimethylphenylammonium hydroxide, Safety of 3-Chloro-2,6-dimethoxybenzoic acid, the publication is Journal of the Chemical Society, Perkin Transactions 1 (2002), 2256-2259, database is CAplus.
[Carbonyl-11C]carboxylic acids were synthesized using palladium-mediated reaction of [11C]carbon monoxide with aryl halides/triflates and benzyl halides in combination with either tetramethylammonium hydroxide or trimethylphenylammonium hydroxide. The radiochem. yields were in the range 20-85%. In a typical experiment starting with 2.1 GBq[11C]carbon monoxide, 0.6 GBq of HPLC-purified 1-[carbonyl-11C]naphthoic acid was obtained within 25 min of the start of the carbonylation reaction (67% decay-corrected radiochem. yield). The specific radioactivity of [carbonyl-11C]nicotinic acid was in the order of 750 GBq μmol-1 using 10.0 μAh bombardment. [Carbonyl-13C]nicotinic acid was synthesized to verify the position of the labeling (δ 166.1) determined by 13C NMR.
Journal of the Chemical Society, Perkin Transactions 1 published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C9H9ClO4, Safety of 3-Chloro-2,6-dimethoxybenzoic acid.
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