Karpina, V. R. published the artcileThe synthesis and biological assessment of [[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides with an 1,2,4-oxadiazole cycle in positions 6, 7 and 8, SDS of cas: 6313-54-8, the publication is Zhurnal Organichnoi ta Farmatsevtichnoi Khimii (2019), 17(1), 28-35, database is CAplus.
A novel method was developed for the synthesis of 32 analogs of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides and biol. assessment was conducted. A convenient scheme for the synthesis of the title compounds started from com. available 2-chloropyridine-3-/4-/5-carboxylic acids with amidoximes to form the corresponding 2-chloro-[1,2,4-oxadiazol-5-yl]pyridines then followed by the hydrazinolysis with an excess of hydrazine hydrate. The process continued via the ester formation with the pyridine ring closure, followed by amide formation. A series of new 2-[6/7/8-(1,2,4-oxadiazol-5-yl)[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides were obtained in good yields and their structures were proved by the method of 1H NMR spectroscopy. The prognosis and study of their pharmacol. activity were also conducted. The synthetic approach of obtaining the representatives of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4] triazolo[4,3-a]pyridine-3-yl]acetamides previously unknown can be used as an applicable method for the synthesis of diverse functionalized [1,2,4]triazolo[4,3-a]pyridine derivatives
Zhurnal Organichnoi ta Farmatsevtichnoi Khimii published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, SDS of cas: 6313-54-8.
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https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics