Lightowler, J. E. published the artcileAnalogs of γ-aminobutyric acid [as anticonvulsant agents], Synthetic Route of 6249-56-5, the publication is Archives Internationales de Pharmacodynamie et de Therapie (1963), 145(1/2), 233-42, database is CAplus.
Owing to the role of p-aminobutyric acid (I) in the central nervous system, experiments were made on the action of various I derivatives and other compounds against convulsive agents such as strychnine (II), leptazol (III), and Megimide (IV). The compounds were usually injected into the tail veins of mice. The compounds tested (full chem. names given) for anticonvulsant activity and for 24-hr. L.D.50 values in mice were mostly compounds of the DF series. In some experiments the anticonvulsant effects were determined by oral administration. None of the L.D. series of compounds had any strongly antagonistic action against II, III, or IV, although in certain cases limited antagonistic effects were obtained. I itself gave no protection against II convulsions. Troxidone (V) was active against both III and IV, which may be of interest since V is chemically related to DF 666 (2-pyrroli-dinone) which has been suggested as a biol. precursor of I. Except for I, the compounds showed little activity against histamine or acetylcholine applied to the isolated guinea pig ileum. I alone had a direct effect on the isolated ileum. Following previous stimulation, the application of I caused an extremely rapid contraction and relaxation. Up to about 100 mg./ml., this effect increased with the concentration of I, but could only be repeated after a considerable time had elapsed between subsequent applications. 19 references.
Archives Internationales de Pharmacodynamie et de Therapie published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Synthetic Route of 6249-56-5.
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