Rhee, Hee-Kyung published the artcileSynthesis, cytotoxicity and topoisomerase II inhibitory activity of benzonaphthofurandiones, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Bulletin of the Korean Chemical Society (2011), 32(7), 2391-2396, database is CAplus.
Benzonaphthofurandiones containing 4 coplanar fused aromatic rings were synthesized and evaluated for their cytotoxicity against human cancer cell lines and for their inhibitory activity on topoisomerases. These benzonaphthofurandiones were prepared by condensation of 2,3-dichloronaphthoquinone and aromatic diols with base catalysts in alc. The synthesized compounds were O-alkylated with (dialkylamino)alkyl halides. The resulting hydroxy derivatives exhibited relatively potent cytotoxicity among the prepared compounds These compounds were evaluated as excellent inhibitors against topoisomerase II (topo II). Especially, a hydroxy analog with a branched Me side chain showed high cytotoxicity against cancer cell lines and good inhibitory activity on topo II.
Bulletin of the Korean Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.
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