Song, Song published the artcileDMSO-catalysed late-stage chlorination of (hetero)arenes, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid, the publication is Nature Catalysis (2020), 3(2), 107-115, database is CAplus.
A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications.
Nature Catalysis published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C19H14O2, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics