Fenxi Ceshi Xuebao published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C10H10O2, Application of Coumarin-6-sulfonyl chloride.
Yang, Shizhong published the artcilePreliminary study on 6-coumarinsulfonyl chloride as luminescence labeling reagent, Application of Coumarin-6-sulfonyl chloride, the publication is Fenxi Ceshi Xuebao (1993), 12(3), 49-52, database is CAplus.
Excessive 6-coumarinsulfonyl chloride (C6SCL) is reacted with L-alanine in pH 9.11 buffer solution (H3BO3-NaOH) at 40°C for 40 min and the reaction mixture is extracted with Et acetate. When the extract is dropped on a polyamide membrane and developed with formic acid-water (1 + 1) solution, the alanine C6SCL derivative is separated The Rf value is 0.67, 0.47 and 0.50 for the derivative, C6SCL and C6SOH, resp. After spraying the spot of derivative with 1 mol L-1 NaOH solution and pre-illuminating and drying under UV light for 10 min, fluorescence intensity of the spot has a good linear relationship with amount of alanine in the range of (4-60) × 10-11 mol. In addition, more intensive room temperature phosphorescence (RTP) of the derivation is induced by using 1.0 mol/L Pb(OAc)2 as the heavy atom perturber and filter paper as solid substrate. All results show that the C6SCL can be expected to serve as not only a fluorescence labeling reagent, but also a RTP one for amino acid etc.
Fenxi Ceshi Xuebao published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C10H10O2, Application of Coumarin-6-sulfonyl chloride.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
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