Zhang, Xiulan published the artcileSynthesis and insecticidal evaluation of novel anthranilic diamides containing N-substituted nitrophenylpyrazole, HPLC of Formula: 350-30-1, the publication is Bioorganic & Medicinal Chemistry (2014), 22(1), 186-193, database is CAplus and MEDLINE.
To cope with developing pest resistance and ecol. problems associated with conventional insecticides and to search for potent insecticides targeting at ryanodine receptor (RyR), a series of novel anthranilic diamides containing N-substituted nitrophenylpyrazole I [R1 = Me, Et, cyclohexyl, etc.; R2 = 2,4-(O2N)2C6H3, 2-Cl-6-O2NC6H3, 2-Cl-4-O2NC6H3] were designed and synthesized. The insecticidal activities of target compounds against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella) were evaluated in the greenhouse by bio-assay tests and the relative structure-activity relationships were briefly discussed. Most compounds exhibited moderate to high activities, in which I [R1 = t-Bu; R2 = 2-Cl-6-O2NC6H3] and I [R1 = cyclopropyl; R2 = 2-Cl-4-O2NC6H3] showed high activity against oriental armyworm and K2 and K4 against diamondback moth even better than the control-chlorantraniliprole. The calcium imaging technique was used to investigate the effects of several typical title compounds on the [Ca2+]i, especially the effects of I [R1 = t-Bu; R2 = 2-Cl-6-O2NC6H3] on the intracellular calcium ion concentration ([Ca2+]i) in neurons, which indicated that some title compounds were potent activators of the RyR.
Bioorganic & Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C10H10CoF6P, HPLC of Formula: 350-30-1.
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