Coote, Susannah C. published the artcileStereoselective aziridination of cyclic allylic alcohols using chloramine-T, Application In Synthesis of 7080-50-4, the publication is Organic & Biomolecular Chemistry (2008), 6(23), 4299-4314, database is CAplus and MEDLINE.
The stereoselective aziridination of a range of cyclic allylic alcs. using two different chloramine salts (4-MeC6H4SO2NClNa, TsNClNa and Me3CSO2NClNa, BusNClNa) has been explored. The stereoselectivity of these reactions was highly dependent on the structure of the allylic alc. and the chloramine salt. Generally, mixtures of cis- and trans-hydroxy aziridines were obtained, in which the major diastereomer was the cis-hydroxy aziridine, while complete cis-diastereoselectivity was observed in the aziridination of 1,3-disubstituted allylic alcs. In each case studied, aziridination using BusNClNa gave higher cis-stereoselectivity than that observed for the same reaction using TsNClNa. Unexpectedly, application of the aziridination conditions to 1-substituted cyclopent-2-en-1-ols did not generate the aziridines. Instead, epoxy sulfonamides were obtained.
Organic & Biomolecular Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Application In Synthesis of 7080-50-4.
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