Florvall, Lennart published the artcilePotential neuroleptic agents. 2,6-Dialkoxybenzamide derivatives with potent dopamine receptor blocking activities, Category: chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (1982), 25(11), 1280-6, database is CAplus and MEDLINE.
Nineteen novel N-(2-pyrrolidinylmethyl)benzamides I (R = OMe, OEt, OCHMe2, or Cl; R1 and R2 = H, Br, or Cl; R3 and R4 = H or Et) were synthesized and tested for dopamine receptor blockade in vivo by their ability to block the apomorphine syndrome in the rat. Several compounds were more potent than sulpiride as dopamine receptor blockers and displayed low liability to induce extrapyramidal side effects (catalepsy) in the rat. The blockade of dopamine receptor activity in vivo was mainly confined to the levorotatory isomers having the S absolute configuration. Structure-activity relationships are discussed.
Journal of Medicinal Chemistry published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C9H9ClO4, Category: chlorides-buliding-blocks.
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https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics