Joyeau, Roger published the artcileN-Aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of β-lactamases, HPLC of Formula: 18791-02-1, the publication is Journal of Medicinal Chemistry (1988), 31(2), 370-4, database is CAplus and MEDLINE.
N-Aryl-3-haloazetidinones I (R = F, R1 = H, F, Br; R = Br, R1 = H, Br) were prepared by amidating BrCH2CRR1COCl, ring closure of BrCH2CRR1CONHC6H3(Me)CO2CMe3-2,5, and ester hydrolysis. Their affinities for the TEM-1 β-lactamase were determined and compared with those of the benzocarbacephems II (R2 = H, Cl, F), and known β-lactamase inhibitors. I and II behave as competitive inhibitors and not as substrates of the enzyme; neither halogen substitution nor ring strain induces enzymic hydrolysis.
Journal of Medicinal Chemistry published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, HPLC of Formula: 18791-02-1.
Referemce:
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