Laurens, J. B. published the artcileValidated method for quantitation of biomarkers for benzene and its alkylated analogues in urine, HPLC of Formula: 33697-81-3, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2002), 774(2), 173-185, database is CAplus and MEDLINE.
A validated gas chromatog.-mass spectrometric method for the anal. of the metabolites of benzene and its alkylated analogs in urine is reported. A number of metabolites, as required by authorities for biomonitoring of industrial exposure to aromatic vapor, were analyzed simultaneously with preservation of quant. information concerning positional isomers. The use of this method replaces a combination of anal. methods required for the anal. of all these metabolites. Urine samples were subjected to acidic deconjugation followed by a derivatization step. Phenol, ortho-, meta-, para-cresol, mandelic acid, and ortho-, meta-, para-methylhippuric acid were analyzed as their corresponding ethoxycarbonyl derivatives, with single ion monitoring. The mass-to-charge ratios (m/z) of the ions used for quantitation by single ion monitoring of the metabolites were: phenol, 94 m/z; cresols, 108 m/z; mandelic acid, 206 m/z; hippuric acid, 105 m/z; methylhippuric acids, 119 m/z. The mass-to-charge ratios for the internal standards were: [2H6]phenol, 99 m/z; p-chlorophenol, 128 m/z and 3-chloro-4-hydroxyphenyl acetic acid, 214 m/z. The limits of detection for phenol and the cresols were below 0.4 μmol/l and below 0.05 μmol/l for mandelic acid and the hippuric acids. Within-run precision for mandelic acid was 6.2%, for hippuric acid was 7.32% and was below 5% for the rest of the analytes.
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, HPLC of Formula: 33697-81-3.
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https://en.wikipedia.org/wiki/Chloride,
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