Safonova, T. S. published the artcileRelation of the antitumor activity of spirobromine analogs to their structure, Application of 2,3-Dibromopropionylchloride, the publication is Khimiko-Farmatsevticheskii Zhurnal (1984), 18(12), 1437-40, database is CAplus.
The dispiropiperazines I [R = CHBrCH2Br, CH:CH2, CHMeCH2Br, CH2CH2NHCH2Ph, (CH2)3Ph, (CH2)3C6H4NO2–p, and (CH2)3C6H4N(CH2CH2Cl)2–p] were prepared and tested along with spirobromine (I, R = CH2CH2Br) [86641-76-1] and 8 dipiperazinylalkanes II (R = Me, H; X = Cl, Br; n = 2, 3, 6, 10) for antitumor activity in sarcoma-bearing rats. Although spirobromine itself showed high antitumor activity, its analogs were only ∼33% as active or completely inactive. Three dipiperazinylalkanes showed very high activity; the others were inactive. Structure-activity relations are discussed.
Khimiko-Farmatsevticheskii Zhurnal published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Application of 2,3-Dibromopropionylchloride.
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