Skerratt, Sarah E. published the artcileIdentification of false positives in “HTS hits to lead”: The application of Bayesian models in HTS triage to rapidly deliver a series of selective TRPV4 antagonists, Related Products of chlorides-buliding-blocks, the publication is MedChemComm (2013), 4(1), 244-251, database is CAplus.
Herein, we describe the discovery and optimization of a series of potent and selective TRPV4 antagonists. The application of a variety of computational techniques (including Bayesian modeling) at the HTS triage stage enabled the early deprioritisation of likely frequent hitters. The use of methods to pos. prioritise compounds for follow-up screening allowed the rapid identification of a number of interesting TRPV4 antagonist series. The hit-to-lead efforts in one such series, the hydroxypiperidines, will be described.
MedChemComm published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C10H14O, Related Products of chlorides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics