Wan, Zhongliang published the artcileSynthesis and Biological Activity of 3-N-Substituted Estrogen Derivatives as Breast Cancer Agents, Product Details of C5H13Cl2N, the publication is Mini-Reviews in Medicinal Chemistry (2013), 13(9), 1381-1388, database is CAplus and MEDLINE.
3-N-substituted-estrogen derivatives I [R = 3-morpholinopropyl, (CH2)3NMe2, CH(Me)CH2NMe2, 3-piperidinopropyl, 3-aminopropyl, etc.] were synthesized and characterized. Their antiproliferative activities against human ER(+) MCF-7 (breast), ER(-) MDA-MB-231 (breast) and Ishikawa (endometrial) cancer cell lines were determined after 72 h drug exposure employing CellTiter-Glo assay at concentrations ranging from (0.01-100,000 nM). The antiproliferative activities of these compounds were compared to tamoxifen (TAM), 4-hydroxytamoxifen (4-OHT, active metabolite of tamoxifen) and raloxifene (RAL). In vitro results indicated that compound I (R = 3-piperidinopropyl) (IC50 = 12μM) displayed comparable antiproliferative activity against MDA-MB 231 cell line; while compounds I [R = (CH2)3NMe2, CH(Me)CH2NMe2, (CH3)3NEt2] (IC50 = 12μM) displayed higher activity against MCF-7 and Ishikawa cell lines, in comparison to TAM activity (19-33μM).
Mini-Reviews in Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C13H17BrO3, Product Details of C5H13Cl2N.
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