Comstock, Lindsay R. published the artcileExpeditious synthesis of aziridine-based cofactor mimics, Name: 2,3-Dibromopropionylchloride, the publication is Tetrahedron (2002), 58(30), 6019-6026, database is CAplus.
S-Adenosyl-L-methionine mimics were synthesized in a linear fashion highlighting methodol. that bypasses the need for adenine base protection. These aziridine-based cofactor mimics are envisioned as useful biochem. tools and potential therapeutic agents whose mechanism of action hinges upon aberrant methyltransferase enzymes. Aziridination of the 5′ position of adenosine was effected by convergence of suitably protected 5′-aminoadenosine with various dibromopropionates. The economy and high yields for this route to said aziridine-based cofactors is highly amenable to large-scale chem. which no doubt will be vital to their development as therapeutics and biochem. tools.
Tetrahedron published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Name: 2,3-Dibromopropionylchloride.
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