Grimova, J. published the artcileTo what extent can results of experimental studies be extrapolated in predicting adverse side effects of drugs in man?, Application In Synthesis of 33697-81-3, the publication is Archives of Toxicology, Supplement (1986), 9(Toxic Interfaces Neurones), 240-3, database is CAplus.
A study of the pharmacokinetics and biotransformation of benzofenac (I) [60736-70-1] was conducted in exptl. animals (rats, rabbits, and dogs) and in human volunteers. The main urinary metabolites in the rat and dog are substances II [33697-81-3], III [90276-10-1], and IV [90276-12-3], and in the rabbit and man II and II. Man differs from animals in the quantities of the individual metabolites. Some metabolites were prepared and tested for embryotoxicity in chicken and rat embryos. Of all the metabolites, metabolite IV is responsible for the embryotoxic action of I. This metabolite never occurs in the rabbit or man. These results substantiate the necessity of carrying out concurrent comparative pharmacokinetic and biotransformation studies of new drugs in exptl. animals and man during the preclin. research stage.
Archives of Toxicology, Supplement published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Application In Synthesis of 33697-81-3.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics