Gupta, Atul published the artcileEvaluation of in-vivo anti-implantation and in-vitro anti-proliferative activities of substituted 3-phenyl-4-phenylvinyl benzopyranone derivatives, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Letters in Drug Design & Discovery (2009), 6(1), 46-50, database is CAplus.
A series of substituted 3-phenyl-4-phenylvinyl benzopyranone derivatives (11a-e) was evaluated for their anti-implantation activity in mature female Sprague-Dawley rat model. Compounds were further evaluated for anti-proliferative activity in human adenocarcinoma breast cancer cell line (MCF-7 cancer cell line). The tested compounds showed significant anti-proliferative activity with moderate anti-implantation activity. The inhibitory concentration (IC50) values of most active compounds 11 (c-e) are 8.43 μM, 7.97 μM and 7.91 μM resp. and comparable to that of tamoxifen (5.10 μM), a well known antiestrogen used for treatment of breast cancer.
Letters in Drug Design & Discovery published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Safety of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.
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