Gupta, Atul published the artcileSynthesis of 3-phenyl-4-phenylvinylbenzopyranones and the corresponding 2,2-dimethylbenzopyrans with structural similarity to estradiol, as estrogen receptor ligands, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Medicinal Chemistry (2007), 3(5), 446-454, database is CAplus and MEDLINE.
7-Methoxy-3-phenyl-4-phenylvinylbenzopyran-2-ones I [R1R2 = oxo, R4 = (CH2)2R5, CH(Me)CH2NMe2, R5 = 1-pyrrolidinyl, 1-piperidinyl, NMe2, NEt2] and the corresponding 2,2-dimethylbenzopyrans I [R1 = R2 = Me] substituted with different alkylamino residues were synthesized. Except compound I [R1R2 = oxo, R4 = CH(Me)CH2NMe2], all compounds showed high levels of estrogen agonistic activity (>81 %) whereas, compounds I [R1R2 = oxo, R4 = (CH2)2R5, CH(Me)CH2NMe2, R5 = 1-piperidinyl, NMe2, NEt2] and I [R1 = R2 = Me, R4 = (CH2)2R5, R5 = 1-pyrrolidinyl] showed significant estrogen antagonistic activity (>20 %). X-Ray anal. of I [R1R2 = oxo, R4 = (CH2)2NEt2] showed its structural resemblance to endogenous estrogen, 17β-estradiol. Estrogenic and anti-estrogenic activities of these derivatives demonstrate their estrogen receptor (ER) binding ability. The lack of hydroxyl groups at appropriate positions resulted in poor relative binding affinity (RBA).
Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Application of 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.
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