Hayakawa, Ichiro published the artcileStructure-activity relationship study of gatastatin based on the topliss tree approach, Application In Synthesis of 620-20-2, the publication is Heterocycles (2019), 99(1), 238-247, database is CAplus.
Various analogs of gatastatin I [Ar = 3-ClC6H4, 4-MeC6H4, 4-tButC6H4, etc.], a γ-tubulin-specific inhibitor, were designed and synthesized by systematically optimizing the aromatic ring at the O7-benzyl group in accordance with an operational Topliss tree, and their biol. activities were evaluated. Some derivatives showed stronger cytotoxicity against HeLa cells than gatastatin. Especially, the cytotoxicity of the I [Ar = 3-ClC6H4] derivative was about 18-fold stronger than that of gatastatin. However, these derivatives did not exhibit binding ability to the yeast γ-tubulin small complex or inhibitory activity against α,β-tubulin polymerization These results suggested that γ-tubulin strongly recognized the unsubstituted Ph ring of the O7-benzyl group in gatastatin.
Heterocycles published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Application In Synthesis of 620-20-2.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics