Kamenova-Nacheva, Mariana published the artcileSynthesis of ferrocenylmethylidene and arylidene substituted camphane based compounds as potential anticancer agents, HPLC of Formula: 21286-54-4, the publication is New Journal of Chemistry (2017), 41(17), 9103-9112, database is CAplus.
Herein is described the synthesis of (+)-camphor derivatives containing sulfonamide groups, ferrocenylmethylidene or arylidene moieties. The obtained derivatives were tested against seven human cancer cells lines, namely BV-173, K-256a, NB-4, A549, H1299, MCF-7, and MDA-MB231, and two normal human cell lines, HEK293 and HUVEC, to determine their activity against malignant cells. Some of them exhibit IC50 values below 10 μM in at least one of the cancer cell lines. Ferrocenylmethylidene ketone 16 (1-((1S,4S)-3-((E)-ferrocenylmethylidene)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)-N-(tert-butyl)methanesulfonamide) can be outlined as the most potent and selective in the current study (IC50 for cancer cells – up to 4.0 μM; IC50 for HEK293 and HUVEC – 68 and 69 μM, resp.). There is a clear trend showing that the presence of a conjugated ferrocenylmethylidene group is essential for the cytotoxicity, however different sulfonamide substituents and derivatization of the carbonyl group can modify the activity. Thus, this class of compounds could have good prospects for further structural optimization.
New Journal of Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.
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