Li, Qiang-Qiang published the artcileDirect Wittig Olefination of Alcohols, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Organic Chemistry (2018), 83(1), 296-302, database is CAplus and MEDLINE.
Benzylic alcs. such as benzyl alc. underwent chemoselective and diastereoselective Wittig olefinations with alkyltriphenylphosphonium salts such as 2-pyridinylmethyltriphenylphosphonium chloride mediated by t-BuOK and air in THF to give aryl alkenes such as (E)-2-(2-phenylethenyl)pyridine in 8-93% yields and in ≥8:1 E:Z diastereoselectivities. Benzylic alcs. were thus directly transformed to olefins without pre-preparation of either aryl aldehydes or ylides. 1,2-Benzenedimethanol underwent chemoselective Wittig olefination to give mono- or dialkenylbenzenes; an unsym. dialkenylbenzene was also prepared The method was used to prepare the potential antitumor agent DMU-212, resveratrol, and nonracemic hexahelicenol enantiomers. The mechanism and kinetics of the olefination were studied.
Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.
Referemce:
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