Millet, Antoine published the artcileDiscovery and Optimization of N-(4-(3-Aminophenyl)thiazol-2-yl)acetamide as a Novel Scaffold Active against Sensitive and Resistant Cancer Cells, COA of Formula: C9H5ClO4S, the publication is Journal of Medicinal Chemistry (2016), 59(18), 8276-8292, database is CAplus and MEDLINE.
Cancer is the second cause of deaths worldwide and is forecast to affect more that 22 million people in 2020. Despite dramatic improvement in its care over the last two decades, the treatment of resistant forms of cancer is still an unmet challenge. Thus, innovative and efficient treatments are still needed. In this context, the authors report herein the synthesis and evaluation of a new class of bioactive mols. belonging to the N-(4-(3-aminophenyl)thiazol-2-yl)acetamide family. Structure-activity relationships could be driven and resulted in the discovery of lead compound I.. The latter display high in vitro potency against both sensitive and resistant cancer cell lines on three models: melanoma, pancreatic cancer, and chronic myeloid leukemia (CML). I leads to cell death by concomitant induction of apoptosis and autophagy, shows good pharmacokinetic properties, and demonstrates a significant reduction of tumor growth in vivo on A375 xenograft model in mice.
Journal of Medicinal Chemistry published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, COA of Formula: C9H5ClO4S.
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