Nagarajaiah, H. published the artcileSequential One-Pot Synthesis of 2-Aminothiazoles Using Corresponding Ketones: Insights into Their Structural Features, Safety of 1-(4-Chlorophenyl)thiourea, the publication is Polycyclic Aromatic Compounds (2022), 42(4), 1909-1919, database is CAplus.
2-Aminothiazoles have been synthesized by a one-pot, two-step sequential procedure in solution state which does not involve the isolation of intermediates. It involves α-halogenation of corresponding precursor ketones followed by condensation with substituted thiourea derivatives All the products were analyzed by IR, NMR, mass spectral techniques and four of them were evaluated crystallog. One of them crystallizes in the triclinic crystal system with space group P, while, all the other compounds crystallize in the monoclinic crystal system in two different space groups viz. P21/c and P21/n. The modified 2-aminothiazole core did not show any change in the intermol. interaction. The N-H… N interaction predominates over other interactions forming centrosym. head to head dimer with the neighboring atoms. This feature is observed in all the mols. except N-(4-(4-bromophenyl)-3-(2,5-dimethylphenyl)thiazol-2(3H)-ylidene)-2,5-dimethylaniline.
Polycyclic Aromatic Compounds published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Safety of 1-(4-Chlorophenyl)thiourea.
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