Neyt, N. C. published the artcileBatch-flow hybrid synthesis of the antipsychotic clozapine, Name: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, the publication is Reaction Chemistry & Engineering (2018), 3(1), 17-24, database is CAplus.
The implementation of an on-the-fly purification by trituration which was also utilized to perform solvent swaps. This above concept demonstrated through the synthesis of the antipsychotic clozapine. In addition, reported a novel means of performing a reduction of an aryl nitro group under flow conditions and an overall improved process route for the total synthesis of clozapine.
Reaction Chemistry & Engineering published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Name: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics